Imaging mass spectrometry (MS) has a unique ability to acquire molecule- and element-specific pictures on a micrometer to submicrometer spatial regime. It has created fascinating opportunities in many research fields, including biochemistry, biotechnology, microelectronics, materials science, and geochemistry. Indeed, the trend toward miniaturization in many areas has driven the mass spectrometry community to improve the sensitivity and the spatial (position) resolution of imaging techniques.