A severe and sometimes fatal form of skin rash characterized by red, blistered spots on the skin; blisters in the mouth, eyes, genitals, or other moist areas of the body; peeling skin that results in painful sores; and fever, headache, and other flu-like symptoms. Internal organs may also be affected. Stevens-Johnson syndrome (SJS) may occur as a severe reaction to certain drugs, including some antiretroviral (ARV) HIV drugs.