- Industry: Library & information science
- Number of terms: 152252
- Number of blossaries: 0
- Company Profile:
The National Library of Medicine (NLM), on the campus of the National Institutes of Health in Bethesda, Maryland, is the world's largest medical library. The Library collects materials and provides information and research services in all areas of biomedicine and health care.
The specific portion of a chromosome or a gene that, when altered in some way (deleted, duplicated, or otherwise mutated), produces the characteristic set of phenotypic abnormalities associated with a particular syndrome or disorder.
Industry:Medical
Identification of mutations by electrophoresis of double-stranded DNA samples through a denaturing gradient, such as urea. Certain mutations affect the migration pattern by changing the point in the gel at which the DNA denatures; mutant sequences can be distinguished from wild-type sequences by comparing the electrophoretic pattern.
Industry:Medical
The study of the structure, function, and abnormalities of human chromosomes.
Industry:Medical
1) An embryonic movement that involves streaming of material from the dorsal and lateral surfaces of the gastrula toward the blastopore and concurrent shifting of lateral materials toward the middorsal line and that is a process fundamental to the establishment of the germ layers.
2) Independent development of similar characters (as of body structure in whales and fishes) by animals or plants of different groups that is often associated with similarity of habits or environment. 3: Movement of the two eyes so coordinated that the images of a single point fall on corresponding points of the two retinas. 4: Overlapping synaptic innervation of a single cell by more than one nerve fiber.
Industry:Medical
An alteration in a gene that is present for the first time in one family member as a result of a mutation in a germ cell (egg or sperm) of one of the parents or in the fertilized egg itself.
Industry:Medical
1) A special type of antigen-presenting cell (APC) that activates T lymphocytes.
2) Any of various antigen-presenting cells with long irregular processes.
Industry:Medical
1) The process of joining two complementary strands of DNA or one each of DNA and RNA to form a double- stranded molecule.
2) Hybridization is the process of combining two complementary single-stranded DNA or RNA molecules and allowing them to form a single double-stranded molecule through base pairing. In a reversal of this process, a double-stranded DNA (or RNA, or DNA/RNA) molecule can be heated to break the base pairing and separate the two strands. Hybridization is a part of many important laboratory techniques such as polymerase chain reaction and Southern blotting.
Industry:Medical
The hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root, which is harder and denser than bone but softer than enamel, and is thus readily abraded when left unprotected.
Industry:Medical
1) Obsessive or uncontrollable use of obscene language.
2) The use of obscene (as scatological) language as sexual gratification.
Industry:Medical
1) A group of overlapping clones representing regions of the genome; the contiguous sequence of DNA created by assembling these overlapping chromosome fragments.
2) Group of cloned (copied) pieces of DNA representing overlapping regions of a particular chromosome.
3) A contig--from the word "contiguous"--is a series of overlapping DNA sequences used to make a physical map that reconstructs the original DNA sequence of a chromosome or a region of a chromosome. A contig can also refer to one of the DNA sequences used in making such a map.
Industry:Medical
