- Industry: Library & information science
- Number of terms: 152252
- Number of blossaries: 0
- Company Profile:
The National Library of Medicine (NLM), on the campus of the National Institutes of Health in Bethesda, Maryland, is the world's largest medical library. The Library collects materials and provides information and research services in all areas of biomedicine and health care.
Greatest concentration or amount of a substance, found by experiment or observation, that causes no alterations of morphology, functional capacity, growth, development, or life span of target organisms distinguishable from those observed in normal (control) organisms of the same species and strain under the same defined conditions of exposure.
Industry:Biology; Chemistry
Greatest concentration or amount of a substance, found by experiment or observation, which causes no detectable adverse alteration of morphology, functional capacity, growth, development, or life span of the target organism under defined conditions of exposure.
Industry:Biology; Chemistry
Group of proteins whose synthesis is increased by increased transcription when cells are exposed to elevated temperatures.
Note: Production of high levels of heat shock proteins can also be triggered by exposure to different kinds of environmental stress conditions, e.g., infection, inflammation, exposure of the cell to chemicals (such as ethanol, arsenicals, or certain metal species), ultraviolet light, starvation, hypoxia (oxygen deprivation), nitrogen deficiency (in plants), or water deprivation. Hence, the alternative name, stress proteins. Their upregulation is sometimes described more generally as part of the stress response.
Industry:Biology; Chemistry
Group of proteins whose synthesis is increased by increased transcription when cells are exposed to elevated temperatures.
Note: Production of high levels of heat shock proteins can also be triggered by exposure to different kinds of environmental stress conditions, e.g., infection, inflammation, exposure of the cell to chemicals (such as ethanol, arsenicals, or certain metal species), ultraviolet light, starvation, hypoxia (oxygen deprivation), nitrogen deficiency (in plants), or water deprivation. Hence, the alternative name, stress proteins. Their upregulation is sometimes described more generally as part of the stress response.
Industry:Biology; Chemistry
Grouping of organisms (micro-organisms, plants, animals) interacting together, with and through their physical and chemical environments, to form a functional entity within a defined environment.
Industry:Biology; Chemistry
Half life of a fraction of a substance in a specific organ or compartment if it defines approximately the overall clearance rate for that substance at a specific time point.
Industry:Biology; Chemistry
Having an affinity for fat and high lipid solubility.
Note: This is a physicochemical property which describes a partitioning equilibrium of solute molecules between water and an immiscible organic solvent, favoring the latter, and which correlates with bioaccumulation.
Industry:Biology; Chemistry
Heme-containing protein in red blood cells with an important function in transporting oxygen from the lungs to body tissues.
Industry:Biology; Chemistry
Hereditary disorder affecting iron metabolism in which excessive amounts of iron accumulate in the body tissues.
Note: The disorder is characterized by diabetes mellitus, liver dysfunction, and a bronze pigmentation of the skin.
Industry:Biology; Chemistry
Human dose of an agent that is believed to induce the same magnitude of a toxic effect that the known animal dose has induced.
Industry:Biology; Chemistry
